Figure 3 | Scientific Reports

Figure 3

From: Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine

Figure 3

Effects of DG and VLX on behavioural changes in depressed mice after treatment. (A) SI ratio at baseline and after 2, 4, and 6 weeks of treatment. Until week 6, VLX (n = 10) and DG-treated (n = 11) depressed mice exhibited a higher SI ratio compared with DEP (n = 10) mice. *P = 0.021 (DG vs. DEP); *P = 0.010 (VLX vs. DEP), by one-way ANOVA, followed by post hoc Dunnett’s test. (B) Sucrose preference after 6 weeks of treatment (n: DEP = 10, DG = 11, VLX = 10). (C) The immobility time in the FST after 6 weeks of treatment. DG-treated (n = 11) mice exhibited less immobility time compared with DEP (n = 10) mice or VLX (n = 10) mice. **P = 0.000 (DG vs. DEP); *P = 0.025 (DG vs. VLX), by one-way ANOVA, followed by post hoc least significant difference test. (D) Immobility time in the TST after 6 weeks of treatment (n: DEP = 10, DG = 11, VLX = 10). All data are represented as mean ± SEM, *P < 0.05 and **P < 0.01. DEP, vehicle-treated mice; DG, diterpene ginkgolides-treated mice; VLX, venlafaxine-treated mice.

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