Figure 3
iNSC Treatment Results in Improved White Matter Integrity After Stroke. DTI was performed 24 hours post-stroke and 1, 4, and 12 weeks post-transplant, and FA was calculated within the peri-infarct of the ipsilateral hemisphere and a comparable anatomical region on the contralateral hemisphere. Representative FA maps of non-treated (A) and iNSC treated (B) animals. The average change in FA in the abnormal territory relative to the contralateral normal control hemisphere was calculated at each time point, and iNSC treatment resulted in enhanced recovery of FA in the ipsilateral hemisphere 12 weeks post-transplant compared to 24 hours post-stroke (C). Data are expressed as mean ± s.d. Data is generated from scans of 4 animals per treatment group. #Indicates significance in FA from 24 hours post-stroke within treatment (p < 0.005).
