Figure 9
iNSC Treatment Leads to Distinct Changes in Gene Expression Related to Tissue Recovery in Gray and White Matter. Quantitative RT-PCR was performed on iNSC treated and non-treated gray and white matter tissue samples. Graph represents relative fold change of iNSC treated gray and white matter relative to non-treated gray and white matter samples. There was a significant upregulation in the expression of the genes ANG1, BDNF, GDNF, IL-10, NOG, NTF3, and RTN4 in iNSC treated gray matter samples relative to non-treated gray matter samples. There was a significant downregulation in the expression of the genes CSF2, IL-1β, and IL-6 in iNSC treated white matter samples relative to non-treated white matter samples. Data are expressed as mean ± s.e.m. *Indicates significance from non-treated sample within tissue type (p < 0.05). Data is generated from one brain sample from each animal (n = 4 per treatment group).
