Figure 1 | Scientific Reports

Figure 1

From: Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

Figure 1

20β-Dihydrocortisol (20β-DHF) is an abundant cortisol metabolite which is increased in plasma and urine of obese horses. (A) Obese horses excreted significantly more urinary β-cortol, β-cortolone and 20β-DHF than lean horses as measured by GC-MS/MS. (B) Plasma 20β-DHF concentrations were significantly higher in obese horses compared to lean horses. (C) Hepatic 20β-DHF concentrations did not differ between lean and obese horses. (D) Visceral adipose 20β-DHF concentrations did not differ between lean and obese horses. Data are mean ± SEM, n = 14/group, *P < 0/05.

Back to article page