Figure 5 | Scientific Reports

Figure 5

From: Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity

Figure 5

20β-Dihydrocortisol induces similar co-regulator interactions with GR as dexamethasone MARCoNI analysis of co-activator recruitment showed that on binding 20β-DHF, GR recruited 36% of the co-regulators recruited by dexamethasone. The colour of the bar represents the modulation index i.e. compound induced log-fold change of binding, red a positive fold change and blue a negative fold change. *P < 0.05, **P < 0.01, ***P < 0.001 compared to the unbound receptor.

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