Figure 4

Determination of significant differentially expressed Aβ proteoforms. Logarithmic ratios of soluble versus insoluble fractions are plotted against the negative logarithmic q-values (q is a false discovery rate corrected p-value, where q ≤ 0.05 is considered statistically significant; above horizontal line) of the hierarchical linear model with replicates nested within participants and participants treated as random effects to test the fixed effect difference between soluble and insoluble aggregates. Vertical lines designate the logarithmic ratio indicating ±2-fold change. All Aβ proteoforms are listed in Supplementary Table 3 with their respective q-values and log₂ fold change. Ox., Oxidation; Amm, ammonium ion; M, methionine; A, alanine.