Table 1 Echocardiography measurements in 15-epi-LXA4 treated and MI-control mice post-MI.
Parameters/groups | d0 naïve control | MI-day 1 | MI-day 5 | ||||
|---|---|---|---|---|---|---|---|
MI-control | Lipo-15-epi-LXA4 | 15-epi-LXA4 | MI-control | Lipo-15-epi-LXA4 | 15-epi-LXA4 | ||
n | 6 | 9 | 8 | 7 | 9 | 6 | 5 |
Heart rate (bpm) | 433 ± 14 | 450 ± 9 | 464 ± 9 | 480 ± 13 | 440 ± 12 | 504 ± 20 | 485 ± 13 |
EDD (mm) | 3.6 ± 0.1 | 4.8 ± 0.2* | 4.4 ± 0.1* | 4.3 ± 0.2 * | 5.6 ± 0.1* | 5.4 ± 0.4* | 5.0 ± 0.3*# |
ESD (mm) | 2.4 ± 0.1 | 4.4 ± 0.1* | 4.0 ± 0.1*# | 3.9 ± 0 0.2*# | 5.3 ± 0.1* | 4.9 ± 0.5*# | 4.6 ± 0.4*# |
Fractional shortening % | 35 ± 2 | 8 ± 1* | 10 ± 1* | 10 ± 1* | 6 ± 1* | 10 ± 2*# | 8 ± 2* |
PWTs (mm) | 1.04 ± 0.05 | 0.54 ± 0.03* | 0.59 ± 0.04* | 0.57 ± 0.04* | 0.54 ± 0.04* | 0.58 ± 0.07* | 0.52 ± 0.03* |
IVSs (mm) | 1.0 ± 0.02 | 0.65 ± 0.05* | 0.63 ± 0.04* | 0.62 ± 0.05* | 0.55 ± 0.03* | 0.74 ± 00.01*# | 0.57 ± 0.09* |
PWTd(mm) | 0.65 ± 0.04 | 0.48 ± 0.04* | 0.52 ± 0.04* | 0.50 ± 0.04* | 0.45 ± 0.03* | 0.48 ± 0.05* | 0.50 ± 0.02* |
IVSd (mm) | 0.71 ± 0.03 | 0.55 ± 0.03* | 0.55 ± 0.03* | 0.52 ± 0.03* | 0.50 ± 0.03* | 0.61 ± 0.02*# | 0.50 ± 0.02* |