Figure 4
From: High-fat diet increases pain behaviors in rats with or without obesity
The low dose DRG inflammation model causes marked pain behaviors in Long-Evans rats maintained on a high-fat diet. The low dose DRG inflammation model was implemented on day 0, after animals had been maintained on the indicated diet for 6 weeks. Baseline behaviors were measured twice just before the pain model was implemented (average plotted on day 0). The high-fat diet group, but not the normal chow group, responded to the DRG inflammation with a marked decrease in von Frey threshold (A) and an increase in dynamic mechanical allodynia (B), cold allodynia (C), and guarding behavior (D). N = 8 Long-Evans rats per group. Each group contains equal numbers of male and female rats; data from males and females have been combined. Data for each sex plotted separately, including animal weights, can be viewed in supplemental Fig. 1. *p < 0.05; **p < 0.01; ***p < 0.001; significant difference between groups at indicated time points (2-way repeated measure ANOVA with Sidak’s multiple comparison posttest; F(1, 14) = 48.9, von Frey data; 10.8, mechanical allodynia data; 67.0, acetone data; 42.5, guarding data).
