Figure 1
From: PPARα activation protects against cholestatic liver injury
ANIT-induced cholestasis coupled to impaired β-FAO in control and ANIT groups. (a) Serum AST, ALT, and ALP enzyme activity. (b) Serum TG and FFA levels. (c) Long-chain acylcarnitine levels. (d) QPCR analysis was performed to measure the gene expression of Cpt1b, Cpt2, Mcad and Hadha. Values represented fold change after normalization to control. (e) Correlation between the levels of 14:0-carnitine and serum bile acids. (f) Correlation between the levels of 16:0-carnitine and serum bile acids. (g) Correlation between the levels of 16:1-carnitine and serum bile acids. (h) Correlation between the levels of 18:1-carnitine and serum bile acids. Correlation factor (r) and P-value were estimated with Pearson’s correlation analysis. All data are repressed as mean ± SEM (n = 8). *P < 0.05, **P < 0.01, and ***P < 0.001 verse control.
