Table 1 Baseline characteristics of the 22 included RCTs.
StudyID | Country | Population(Statin/Control) | Surgery type | Intervention | |||
|---|---|---|---|---|---|---|---|
No. | Age | Man(%) | Statin group | Control | |||
Almansob et al. 201218 | China | 68/64 | 45.5 ± 14.5/41.5 ± 18.7 | 49.20% | Noncoronary cardiac surgery | Routine medication + Simvastatin: 20 mg/day, 5–7 days before surgery and restart in the second day postoperation | Routine medication without statin |
Aydin et al. 201519 | Turkey | 30/30 | 62.6 ± 10.9/62.4 ± 12.2 | 39.20% | CABG | Routine medication + Atrovastatin: 40 mg/day, 6 hours after surgery until postoperaive 1 month | Routine medication without statin |
Baran et al. 201220 | Turkey | 30/30 | 60.8 ± 8.6/62.2 ± 8.1 | 61.70% | CABG | Routine medication + Atrovastatin: 40 mg/day, 14 days before surgery and restart in the first day postoperation | Routine medication + Placebo |
Berkan et al. 200921 | Turkey | 23/23 | 65.4 ± 11.2/67.7 ± 9.6 | 63.00% | CABG + CPB | Routine medication + Fluvastatin: 80 mg/day, 3 weeks before surgery | Routine medication + Placebo |
Billing et al. 201614 | USA | 308/307 | 66 ± 6.7/67 ± 6.3 | 69.40% | Cardiac surgery | Routine medication + Atorvastatin: 80 mg/day, 1 day before surgery and 40 mg/d after surgery until discharge | Routine medication + Placebo |
Caoris et al. 200822 | Chile | 21/22 | 68.2 ± 7.2/67.9 ± 7.3 | 83.70% | CABG | Routine medication + Pravastatin: 40 mg/day, 2 days before surgery and 7 days after surgery with an additional dose of 40 mg at 1 hour after surgery | Routine medication without statin |
Carascal 201623 | Spain | 47/43 | 67.4 ± 11.2; /65.5 ± 12.0 | 65.56% | Valve surgery | Routine medication + atrovastatin 40 mg/d 7days before surgery until lasting 7d after surgery | Routine medication without statin |
Chello et al. 200624 | Italy | 20/20 | 65.7 ± 7.7/63.7 ± 7.1 | 77.50% | CABG + CPB | Routine medication + Atrovastatin: 20 mg/day, 3 weeks before surgery | Routine medication + Placebo |
Chritanson et al. 199925 | Belgium | 40/37 | 62.7 ± 11.3/64.1 ± 10.8 | 79.50% | CABG + CPB | Routine medication + Simvastatin: 20 mg/day, 4 weeks before surgery | Routine medication without statin |
Dehghani et al. 201526 | Iran | 29/29 | 54 ± 6.5/45 ± 6.5 | 32.80% | Valve surgery + CPB | Routine medication + Atrovastatin: 40 mg/day, 3 days before and 5 days after surgery | Routine medication + Placebo |
Ji et al. 200927 | China | 71/69 | 65 ± 6/66 ± 9 | 69.30% | CABG + off-pump | Routine medication + Atrovastatin: 20 mg/day, 7 days before surgery | Routine medication + Placebo |
Makuucdi et al. 200528 | Japan | 152/151 | 59.6 ± 6.5/58.2 ± 7.3 | 84.20% | CABG | Routine medication + Pravastatin: 10–20 mg/day | Routine medication without statin |
Melina et al. 200930 | Italy | 315/317 | NR | NR | CABG + off-pump | Routine medication + Atrovastatin: 40 mg/day before surgery | Routine medication + Placebo |
Mannacio et al. 200829 | Italy | 100/100 | 61.3 ± 9.2/59.3 ± 8.4 | 72.50% | CABG | Routine medication + Rosuvastatin: 20 mg/day, 7days before surgery | Routine medication + Placebo |
Park et al. 201613 | Korea | 100/100 | 58 ± 12/58 ± 14 | 49.50% | Valve surgery | Routine medication + Atorvastatin: 80 mg/day, 1 day before surgery and 40 mg 2 after surgery, with 80 mg the day of surgery | Routine medication + Placebo |
Patti et al. 200631 | Italy | 101/99 | 65.5 ± 8.8/67.3 ± 8.1 | 73.50% | Cardiac surgery + CPB | Routine medication + Atrovastatin: 40 mg/day, 7days before surgery | Routine medication + Placebo |
Prowle et al. 201212 | Australia | 50/50 | 69.0 ± 11.1/67.3 ± 10.8 | 70% | Cardiac surgery + CPB | Routine medication + Atrovastatin: 40 mg/day, 1 day before surgery and 3 days after surgery | Routine medication + Placebo |
Song et al. 20088 | Korea | 62/62 | 61.7 ± 9.9/64.0 ± 9.2 | 65.30% | CABG + off-pump | Routine medication + Atrovastatin: 30 mg/day, 3 days before surgery and 30 days after surgery | Routine medication + Placebo |
Sun et al. 201132 | China | 49/51 | 64 ± 7/65 ± 8 | 67% | CABG + CPB | Routine medication + Atrovastatin: 20 mg/day, 7 days before surgery | Routine medication + Placebo |
Tamayo et al. 200917 | Spain | 22/22 | 67.7 ± 7.3/68.0 ± 6.9 | 79.50% | CABG + CPB | Routine medication + Simvastatin: 20 mg/day, 3 weeks before surgery | Routine medication without statin |
Vukovic et al. 201133 | Serbia | 29/28 | 61.3 ± 7.7/61.8 ± 7.4 | 84.20% | CABG | Routine medication + Atorvastatin :20 mg/day, 3 weeks before surgery | Routine medication + Placebo |
Zheng et al. 201634 | China | 960/962 | 59.3 ± 9.4/59.5 ± 9.5 | 79.20% | CABG + Valve surgery | Routine medication + Rosuvastatin: 20 mg/day, 8 days before surgrey and 5 days after surgery | Routine medication + Placebo |
