Table 3 Comparison with previous meta-analyses.

From: Perioperative statin administration with decreased risk of postoperative atrial fibrillation, but not acute kidney injury or myocardial infarction: A meta-analysis

Study

No. of trials

Primary Outcome

Secondary outcomes

Chemical indexes

Main results (OR/RR)

Patti et al.7

11 RCTs

POAF

Myocardial injury, MACE, mortality, stroke

CRP

POAF: 0.41 (0.31 to 0.54)

Putzu et al.37

23 RCTs (including cross-over trial)

AKI, POAF, MI, stroke, infection

Mortality

NR

POAF: 0.80 (0.70 to 0.91) AKI: 1.18 (0.99 to 1.41)

Rezaei et al.38

12 RCTs (including cross-over trial)

POAF

Duration of MV, ICUstay, HLOS

CRP

POAF: 0.50 (0.41 to 0.61)

Xiong et al.39

9 RCTs

AKI, RRT

ICUstay, HLOS

Scr, CRP

AKI: 1.12 (0.97 to 1.29)

Yuan et al.40

20 RCTs (including cross-over trial)

POAF, AKI, mortality

MI, stroke, ICU stay, HLOS

Scr

POAF: 0.50 (0.34 to 0.73) AKI: 1.01 (0.75 to 1.36)

Current one

22 RCTs

POAF, AKI, MI

Mortality, ICU length of stay, HLOS

CRP, IL-6, cTn at different time

POAF: 0.69 (0.56 to 0.86) AKI: 0.98 (0.70 to 1.35) MI: 0.84, (0.58 to 1.23)

  1. RCTs, randomized controlled trials; POAF, postoperative atrial fibrillation; AKI, acute kidney injury; CRP, C-reaction protein; MI, myocardial infarction; ICU, intensive care unit; HLOS, hospital length of stay; Scr, serum creatinine; MACE, major adverse cardiovascular events; MV, mechanical ventilation.
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