Table 2 Genotype among cases and controls and their association withT2DN risk.
From: SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
SNP | Case(%) | Control(%) | Pa | OR(95%CI)b | Pb | OR(95%CI)c | Pc |
|---|---|---|---|---|---|---|---|
rs3818292 | |||||||
AA | 360(55.13) | 226(54.72) | 1 | 1 | |||
AG | 242(37.06) | 146(35.35) | 1.04(0.80, 1.36) | 0.770 | 1.01(0.76, 1.35) | 0.940 | |
GG | 51(7.81) | 41(9.93) | 0.26 | 0.78(0.50, 1.22) | 0.270 | 0.69(0.43, 1.11) | 0.120 |
AG + GG | 293(44.87) | 187(45.28) | 0.98(0.77, 1.26) | 0.900 | 0.94(0.72, 1.23) | 0.650 | |
AA + AG | 602(92.29) | 372(90.07) | 1 | 1 | |||
GG | 51(7.81) | 41(9.93) | 0.77(0.50, 1.18) | 0.70(0.44, 1.11) | 0.120 | ||
A | 962(73.66) | 598(72.40) | 1 | ||||
G | 344(26.34) | 228(27.60) | 0.94(0.77, 1.14) | 0.520 | |||
rs4746720 | |||||||
TT | 191(29.25) | 121(29.30) | 1 | 1 | |||
CT | 331(50.69) | 210(50.85) | 0.99(0.75, 1.33) | 0.990 | 0.90(0.66, 1.23) | 0.500 | |
CC | 131(20.06) | 82(19.85) | 0.60 | 1.01(0.71, 1.45) | 0.950 | 1.01(0.69, 1.46) | 0.990 |
CT + CC | 462(70.75) | 292(70.70) | 0.98(0.77, 1.26) | 0.910 | 0.92(0.69, 1.23) | 0.990 | |
TT + CT | 522(79.94) | 331(80.15) | 1 | 1 | |||
CC | 131(20.06) | 82(19.85) | 1.01(0.75, 1.38) | 0.940 | 1.01(0.72, 1.40) | 0.970 | |
T | 713(54.59) | 452(54.72) | 1 | ||||
C | 593(45.41) | 374(45.28) | 1.00(0.84, 1.20) | 0.950 | |||
rs10823108 | |||||||
GG | 353(54.06) | 224(54.23) | 1 | 1 | |||
GA | 261(39.97) | 148(35.84) | 1.12(0.86, 1.45) | 0.400 | 1.07(0.81, 1.43) | 0.620 | |
AA | 39(5.97) | 41(9.93) | 0.36 | 0.60(0.38, 0.97) | 0.040 | 0.57(0.34, 0.94) | 0.030 |
GA + AA | 300(45.94) | 189(45.77) | 1.01(0.79, 1.29) | 0.950 | 0.97(0.74, 1.27) | 0.820 | |
GG + AG | 614(94.03) | 372(90.07) | 1 | 1 | |||
AA | 39(5.97) | 41(9.93) | 0.58(0.37, 0.91) | 0.020 | 0.56(0.34, 0.92) | 0.020 | |
G | 967(74.04) | 596(72.15) | 1 | ||||
A | 339(25.96) | 230(27.85) | 0.91(0.75, 1.11) | 0.340 | |||
rs17446614 | |||||||
GG | 392(60.03) | 304(73.61) | 1 | 1 | |||
GA | 219(33.54) | 95(23.00) | 1.77(1.33, 2.35) | < 0.001 | 1.54(1.14, 2.13) | < 0.001 | |
AA | 42(6.43) | 14(3.39) | 0.07 | 2.32(1.25, 4.34) | 0.02 | 2.34(1.77, 4.13) | < 0.001 |
GA + AA | 261(39.97) | 109(26.39) | 1.86(1.42, 2.43) | < 0.001 | 1.65(1.19, 2.26) | < 0.001 | |
GG + AG | 611(93.57) | 399(96.61) | 1 | 1 | |||
AA | 42(6.43) | 14(3.39) | 1.96(1.06, 3.63) | 0.03 | 2.07(1.38, 4.14) | < 0.001 | |
G | 1003(76.80) | 703(85.11) | 1 | ||||
A | 303(23.20) | 123(14.89) | 1.73(1.37, 2.18) | < 0.001 | |||
rs2721068 | |||||||
TT | 77(11.79) | 40(9.68) | 1 | 1 | |||
CT | 296(45.33) | 192(46.49) | 0.80(0.53, 1.22) | 0.300 | 0.64(0.40, 1.02) | 0.060 | |
CC | 280(42.88) | 181(43.83) | 0.29 | 0.81(0.53, 1.23) | 0.310 | 0.73(0.46, 1.15) | 0.180 |
CT + CC | 576(88.21) | 373(90.32) | 0.80(0.54, 1.20) | 0.280 | 0.68(0.44, 1.05) | 0.080 | |
TT + CT | 373(57.12) | 232(56.17) | 1 | 1 | |||
TT | 77(11.79) | 40(9.68) | 0.97(0.75, 1.23) | 0.760 | 0.95(0.73, 1.24) | 0.690 | |
T | 450(34.46) | 272(32.93) | 1 | ||||
C | 856(65.54) | 554(67.07) | 0.93(0.78, 1.12) | 0.470 | |||
