Table 3 Stratification analysis of the five SNPs polymorphisms and DN susceptibility.
From: SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy
Variables | rs3818292 AG + GG /AA | rs4746720 TC + CC /TT | rs10823108 GA + AA/GG | rs17446614 GA + AA/GG | rs2721068 TC + CC /TT | |||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95%CI)a | Pb | OR (95%CI)a | Pb | OR (95%CI)a | Pb | OR (95%CI)a | Pb | OR (95%CI)a | Pb | |
Gender | ||||||||||
male | 0.76(0.54, 1.06) | 0.11 | 1.07(0.73, 1.55) | 0.73 | 0.88(0.62, 1.21) | 0.44 | 2.32(1.58, 3.41) | < 0.0001 | 0.47(0.25, 0.87) | 0.02 |
female | 1.32(0.84, 2.08) | 0.23 | 0.77(0.47, 1.25) | 0.29 | 1.06(0.67, 1.68) | 0.79 | 2.67(1.62, 4.40) | < 0.0001 | 0.96(0.51, 1.82) | 0.90 |
Age | ||||||||||
≤60 | 0.79(0.53, 1.16) | 0.23 | 1.06(0.69, 1.64) | 0.78 | 0.91(0.62, 1.34) | 0.63 | 2.65(1.68, 4.18) | < 0.0001 | 0.35(0.17, 0.71) | 0.00 |
>60 | 1.09(0.75, 1.57) | 0.66 | 0.86(0.58, 1.30) | 0.48 | 1.03(0.71, 1.49) | 0.89 | 2.02(1.34, 3.02) | 0.0007 | 1.03(0.57, 1.86) | 0.92 |
Duration of diabetes | ||||||||||
≤10 | 1.01(0.61, 1.68) | 0.97 | 0.95(0.57, 1.59) | 0.85 | 1.00(0.67, 1.57) | 0.99 | 1.03(0.63, 1.67) | 0.53 | 0.63(0.29, 1.37) | 0.25 |
>10 | 0.89(0.64, 1.26) | 0.52 | 0.95(0.66, 1.37) | 0.79 | 0.94(0.67, 1.32) | 0.73 | 1.27(0.55, 2.32) | 0.49 | 0.72(0.42, 1.24) | 0.23 |
BMI | ||||||||||
<24 | 1.23(0.67, 2.28) | 0.50 | 0.79(0.43, 1.43) | 0.43 | 0.66(0.37, 1.16) | 0.15 | 4.60(2.44, 8.66) | <0.0001 | 1.93(0.78, 4.78) | 0.15 |
≥ 24 | 0.95(0.70, 1.29) | 0.75 | 0.97(0.70, 1.36) | 0.89 | 1.06(0.78, 1.44) | 0.70 | 1.89(1.35, 2.65) | 0.0002 | 0.46(0.26, 0.79) | 0.01 |
HbA1C | ||||||||||
≤8 | 1.21(0.83, 1.76) | 0.33 | 0.93(0.62, 1.41) | 0.73 | 1.13(0.78, 1.65) | 0.52 | 1.06(0.58, 1.39) | 0.68 | 0.62(0.34, 1.15) | 0.13 |
>8 | 0.75(0.51, 1.10) | 0.14 | 0.88(0.58, 1.33) | 0.54 | 0.87(0.60, 1.27) | 0.47 | 1.48(0.99, 2.23) | 0.0600 | 0.77(0, 42, 1.41) | 0.40 |
HDL-C | ||||||||||
≤1 | 1.17(0.78, 1.74) | 0.44 | 0.66(0.41, 1.05) | 0.08 | 1.13(0.76, 1.68) | 0.55 | 1.07(0.34, 1.78) | 0.53 | 0.51(0.25, 1.05) | 0.07 |
>1 | 0.83(0.57, 1.20) | 0.31 | 1.21(0.82, 1.79) | 0.36 | 0.88(0.61, 1.27) | 0.48 | 1.09(0.41, 2.11) | 0.78 | 0.81(0.46, 1.46) | 0.49 |
LDL-C | ||||||||||
≤3.5 | 0.93(0.69, 1.25) | 0.62 | 0.93(0.67, 1.28) | 0.64 | 0.95(0.71, 1.27) | 0.71 | 2.21(1.60, 3.06) | <0.0001 | 0.61(0.38, 0.98) | 0.04 |
>3.5 | 0.93(0.40, 2.17) | 0.86 | 0.87(0.35, 2.13) | 0.75 | 0.68(0.29, 1.59) | 0.38 | 1.45(0.96, 2.21) | 0.12 | 1.80(0.54, 6.01) | 0.34 |
TC | ||||||||||
≤5 | 0.84(0.62, 1.15) | 0.28 | 1.03(0.72, 1.45) | 0.88 | 0.81(0.60, 1.11) | 0.20 | 2.29(1.62, 3.22) | <0.0001 | 0.70(0.41, 1.17) | 0.17 |
>5 | 2.11(1.06, 4.21) | 0.03 | 0.78(0.38, 1.60) | 0.49 | 1.92(0.98, 3.79) | 0.06 | 2.57(1.16, 5.70) | 0.0200 | 0.65(0.25, 1.78) | 0.40 |
TG | ||||||||||
≤1.65 | 0.99(0.69, 1.41) | 0.94 | 1.00(0.68, 1.48) | 0.98 | 0.94(0.66, 1.35) | 0.75 | 1.09(0.39, 2.13) | 0.76 | 0.67(0.38, 1.18) | 0.17 |
>1.65 | 1.00(0.65, 1.54) | 0.99 | 0.76(0.47, 1.22) | 0.25 | 1.02(0.67, 1.57) | 0.93 | 1.18(0.73, 2.55) | 0.89 | 0.82(0.39, 1.69) | 0.59 |
Hypertension | ||||||||||
No | 0.94(0.63, 1.41) | 0.76 | 0.97(0.63, 1.51) | 0.90 | 1.01(0.67, 1.52) | 0.95 | 2.68(1.74, 4.14) | <0.0001 | 0.89(0.49, 1.63) | 0.71 |
Yes | 1.00(0.70, 1.42) | 0.98 | 0.88(0.60, 1.31) | 0.53 | 0.95(0.67, 1.35) | 0.78 | 2.03(1.35, 3.05) | 0.0007 | 0.53(0.28, 1.02) | 0.06 |
DM Family history | ||||||||||
No | 0.97(0.69, 1.36) | 0.86 | 0.93(0.64, 1.35) | 0.69 | 1.10(0.78, 1.55) | 0.58 | 2.27(1.55, 3.34) | <0.0001 | 0.50(0.28, 0.91) | 0.02 |
Yes | 0.91(0.60, 1.40) | 0.68 | 0.92(0.57, 1.47) | 0.72 | 0.83(0.54, 1.27) | 0.38 | 2.33(1.45, 3.76) | 0.0005 | 1.12(0.59, 2.14) | 0.74 |
Drinking | ||||||||||
No | 0.92(0.69, 1.23) | 0.58 | 0.85(0.63, 1.18) | 0.35 | 0.96(0.72, 1.28) | 0.76 | 1.52(0.82, 2.49) | 0.56 | 0.85(0.58, 1.33) | 0.47 |
Yes | 1.08(0.54, 2.17) | 0.82 | 2.02(0.87, 4.67) | 0.10 | 1.12(0.56, 2.25) | 0.75 | 1.14(0.54, 2.40) | 0.7300 | 0.75(0.85, 3.59) | 0.13 |
Smoking | ||||||||||
No | 0.96(0.70, 1.31) | 0.79 | 0.84(0.60, 1.17) | 0.30 | 0.95(0.70, 1.30) | 0.74 | 2.35(1.66, 3.31) | <0.0001 | 0.88(0.55, 1.43) | 0.61 |
Yes | 0.93(0.63, 1.61) | 0.79 | 1.12(0.61, 2.06) | 0.71 | 1.05(0.60, 1.83) | 0.87 | 2.06(1.10, 3.85) | 0.0200 | 0.14(0.03, 0.64) | 0.01 |
