Table 2 Statistical results.

From: New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies

PLS Statistics

CoMFA

CoMSIA

q 2

0.611

0.546

r 2

0.940

0.905

S

0.179

0.232

F

96.577

41.575

r 2 bootstrap

0.954

0.923

Sbootstrap

0.160

0.193

Optimal Components

6

8

Field Distribution %

  Steric

71.9

15.2

  Electrostatic

28.1

52.5

Hydrophobic

  Hydrogen Bond Donor

 

22.1

  Hydrogen Bond Acceptor

 

10.1

  r 2 pred

0.759

0.791

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