Figure 1
From: Metal concentrations and distributions in the human olfactory bulb in Parkinson’s disease
Schematic of the laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) process. (a) Matrix-matched, metal-spiked standards and serial sagittal sections of olfactory bulb are cut on a cryostat and mounted onto clean glass slides. (b) Using LA-ICP-MS, these sections are scanned in a raster pattern and (c) counts of metal species are recorded over time. (d) Data are then background corrected and quantified using matrix-matched standard data. (e) Scanned and adjacent non-scanned sections are stained to determine morphology of olfactory bulb, (f) which enables the heat maps to be aligned and generate output.
