Figure 2
From: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer
Susceptibility genetics. (a) Expression and localization in human brain utilizing Allen Brain Atlas of genes with alleles conferring susceptibility to congenital toxoplasmosis in National Collaborative Chicago Based Congenital Toxoplasmosis Study (NCCCTS). Transcript expression is visualized for brain of the youngest donor (H0351.2001, 24 years, male, African-American). Z-score of microarray data ranges between −3 and +3 to quantify the lowest to highest expression (see Supplement B: Table S2). (b) Ingenuity Pathway Analysis (IPA) of NCCCTS susceptibility genes and upstream regulators. Cut off of p value at 5 × 10−3 generated a network of 117 predicted upstream regulators (see Supplement B: Table 2). Upstream regulators and susceptibility genes are consolidated/bundled and graphically mapped. Susceptibility genes are manually relocated in IPA graphic to show connectivity to upstream regulators. Note NFκB and TGFβ are central nodes that are visual.
