Figure 5 | Scientific Reports

Figure 5

From: Topological N-glycosylation and site-specific N-glycan sulfation of influenza proteins in the highly expressed H1N1 candidate vaccines

Figure 5

Topological location of N-glycosylation sites of the influenza proteins from the candidate vaccine of NIBRG-121xp. (A) hemagglutinin (A/California/04/2009 strain, PDB: 3LZG); (B) neuraminidase-receptor (sialic acid) binding region (PDB: 3NSS). The 3D protein structures of influenza HA and NA were visualized using UCSF Chimera program downloaded from the website (https://www.cgl.ucsf.edu). The highly heterogeneous sulfated residues are highlighted in red, whereas the singly glycosylated or non-glycosylated residues with Asn-X-Ser/Thr motif are labeled in grey. Fucosylated glycans, mannose-type glycans, “normal” hybrid and complex glycans of the residues are coloured in pink, green and orange, respectively.

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