Table 2 Summary of sequence conservation on the secondary structural element levels of HSP47/SERPINH1 proteins.

From: Ancestry & molecular evolutionary analyses of heat shock protein 47 kDa (HSP47/SERPINH1)

Structural Components

Sequence Conservation

Status of 51 conserved amino acids $

90–100

70–89

50–69

N-terminal segment

0

8

9

     

hA

3

4

7

F33 !

    

s6B

1

0

2

N49

S53

   

hB

3

4

4

P54

S56

L61

G67

 

hC

2

3

2

T72

L80

   

hD

2

5

5

     

s2A

0

6

3

     

hE

1

5

4

F130

    

s1A

0

1

2

     

hF

3

4

9

F147

I157

N158

V161

T165

Loop between hF/s3A

1

1

2

I169

T180

   

s3A

5

4

8

L184 %

N186

F190

K191

G192

hF1

0

2

1

     

s4C

2

0

3

F198

T203

F208

  

s3C

5

4

2

V218

M220

M221

  

s1B

1

0

1

     

s2B

1

2

1

Y244

    

s3B

0

1

1

L254

P255

   

hG

2

4

1

     

hH

1

1

2

     

s2C

3

2

1

     

s6A

0

1

2

P289

K290

   

hI

4

0

2

L299

L303

G307

  

hI1

0

2

0

     

Loop between hI/s5A

6

6

6

F312

A316

L327

  

s5A

2

3

1

H334

E342

   

s4A (RCL)

3

4

10

G344

A347

   

s1C

3

0

0

     

s4B

2

3

2

P369

F370

   

s5B

2

2

5

L383

F384

G386

  

C terminal end

4

1

5

P391

    
  1. $As proposed by Irving et al. (2000). !Bold – Missing.
  2. %Underscore – Partially present (<50% of HSP47).
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