Figure 1

Statistics of two loci trajectories. (A) Schematic representation of the first encounter time (FET) τ _E (upper) and the first dissociation time (FDT) τ _D (lower). The FET is computed when the two loci are within an encounter distance ε when they are initially apart. The FDT is computed when the distance between two loci is larger than ε when they initially encountered. The genomic distances are \({\rm{\Delta }}\in [25.3,\,100.8]\,{\rm{kbp}}\) between tagged loci. (B) Experimental setting for tagging seven chromatin strains by inserting lac and tet flanking operators at their ends on chromosome 4, 5 and 14²³. (C) Distribution of the FET (left column) and the FDT (right column) with respect to Δ, fitted with a exp (−λt), with a a constant. The R ²–values are computed from the matlab fitting toolbox and the number of events N for the FET and FDT are extracted from trajectories. For the strain 100.8 kbps, we also fitted a sum of two exponentials (dashed green) a exp (−λ ₁ t) + b exp (−λ ₂ t), with a = 2.3 b = 0.15 and λ ₁ = 0.75, λ ₂ = 0.1.