Figure 8 | Scientific Reports

Figure 8

From: A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models

Figure 8

(A) Concentration dependent inhibition of DNA ligase activity by compound 19 at 0, 5, 10 and 20 µM concentrations against different human and non-human ligases. The gel picture and graph clearly showed specific hLigI inhibition activity of compound 19. (B) A representative gel image and graph for inhibition of ligation by compound 19 and their parent molecules at 20 µM concentration. Compound 19 showed significantly better antiligase activity as compared to Neo-tanshinlactone (Neo) and Resveratrol (Res). Compound 23 was used as a positive control. The data shown are mean ± SEM of three independent experiments. Significant difference from control was observed by ANOVA: *P < 0.05, **P < 0.01, ***P < 0.001.

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