Figure 7 | Scientific Reports

Figure 7

From: Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study

Figure 7

Computational analysis of mutation-induced structural changes for LEN T94H, Q89H and Y96Q. Dimer structure of native LEN is shown as a cartoon overlaid with mutant T94H (A), Q89H (B) and Y96Q (C) with the mutated residue side-chains shown as sticks. RMS values between control LEN and mutant are indicated. Expanded regions highlight key areas of interest in greater detail. Control (C) monomers are shown in pink (monomer A) and blue (monomer B), with mutant (M) structures in green (monomer A) and orange (monomer B). Hydrogen bonds are shown as yellow dashed lines with lengths given; changes in lengths are shown in red text on mutant images. Red spheres indicate loss of hydrogen bond.

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