Table 1 Stimulation of VDRE-reporter activity and inhibition of cytokine production by 1,20S(OH)2D3.

From: 1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

Compound

VDRE stimulation (nM)

Cytokine level

HaCaT

Caco-2

Jurkat

IFNγ

IL1β

Control

NA

NA

NA

710 ± 9

123 ± 2

1,20S(OH)2D3

450.4 ± 14.9

284.8 ± 13.2

19.1 ± 0.9

383 ± 3

90 ± 2

1,25(OH)2D3

421.9 ± 3.1

300.2 ± 9.2

2.1 ± 0.1

353 ± 11

121 ± 3

22-Oxa

10.5. ± 2.6

154.5 ± 0.8

1.2 ± 0.1

258 ± 2

91 ± 2

  1. Note: VDRE stimulation activity = EC50 ± standard deviation, cytokine level in splenocyte cultures = value ± standard error of the mean (pg/mL).
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