Figure 5 | Scientific Reports

Figure 5

From: Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing

Figure 5

X-autosomes dosage compensation during development. Mean X:A expression ratio per embryo/sample (mean ± s.e.m. in red). P-values: (**) ≤0.01, (***) ≤0.001 non-paired Wilcoxon test; sex of post-EGA stages is indicated and highlighted by background color: females (F, pink), males (M, blue). Embryos and male hESC (hESCp0) from dataset-2; twin corresponds to ICMs and trophectoderm of a female blastocyst with two ICMs10; Fibrob. is a female fibroblast cell line9; H9, female hESC line11. See Supplementary Table S4, for single-cell X:A expression ratios. Below, the activity of the X chromosomes in the respective embryos/cells. mat(XaXa): maternal mRNA from primordial germ cells with two active X chromosomes; Xa/i: X chromosome undergoing XCI; X2a: upregulated active X.

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