Table 4 Effect of the risk/protective DRB1/DQB1 alleles on the presence/absence of another risk/protective DRB1/DQB1 allele.

From: Principal contribution of HLA-DQ alleles, DQB1*06:04 and DQB1*03:01, to disease resistance against primary biliary cholangitis in a Japanese population

Effect of HLA allele

HLA background

Present

Absent

Effect of DRB1*08:03 in the presence/absence of DQB1*06:04

    Frequencies in subset of patients/controls

5.4%/4.7%

24.1%/16.6%

    Odds ratio (95% CI), p

1.16 (0.24–5.74), p = 0.85

1.59 (1.29–1.97), p = 1.70 × 10 −5

Effect of DQB1*06:04 in the presence/absence of DRB1*08:03

    Frequencies in subset of patients/controls

0.7%/4.5%

3.8%/16.1%

    Odds ratio (95% CI), p

0.15 (0.03–0.73), p = 0.0068

0.21 (0.14–0.30), p = 8.16 × 10 −19

  1. The effect of the most significant risk/protective DRB1 and DQB1 alleles was evaluated by comparing the frequencies between patients with PBC and control population in the presence/absence of another risk/protective allele. Significant differences (p < 0.05) in the comparisons are highlighted in bold.
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