Figure 8 | Scientific Reports

Figure 8

From: Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach

Figure 8

In vivo effects of compound 1 in isovolumetric bladder rat model. The results were given as mean values ± standard error of the mean (sem) of the measurement in 8 different rats. (A) Effects of intravenous administration of vehicle (on the left) and compound 1 at 10 mg/kg (on the right) on micturition frequency (MF). No significant changes were observed upon vehicle administration (on the left), while compound 1 (on the right) significantly reduced MF at 30 min (p < 0.01). (B) Effects of intravenous administration of vehicle and compound 1 at 10 mg/kg on inhibition time. Compound 1 significantly enhanced inhibition time (p < 0.05). (C) Effects of intravescical administration of vehicle and compound 1 at 2.268 mg. Compound 1 significantly increased (p < 0.01) the threshold volume inducing RBC.

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