Table 1 Pathway analysis for the p53-induced and p53-repressed genes.

From: Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells

 

Term

Genes

−log (p value)

Fold enrichment

p53-induced genes

p53 signalling pathway

P21, Bbc3, Z3, Bax, Rprm, Mdm2, Pmaip1, Fas, Perp, Sesn2, Ccng1

12.27

30.49

Cytokine-cytokine receptor interaction

Inhbb, Tnfrsf10b, Gdf5, Eda2r, Fas, Cd137l

2.16

4.7

TGF-beta signalling pathway

Inhbb, Gdf5, Fst

1.15

6.6

Apoptosis

Tnfrsf10b, Bax, Fas

1.15

6.6

p53-repressed genes

Cell cycle

Cdk1, E2f2, Cdc6, Ttk, Chek1, Mcm2, Mcm3, Mcm5, Mcm6, Ccne2, Cdc45, Ccnb2, Plk1, Bub1, Bub1b, Ccna2

10.99

21.1

DNA replication

Prim1, Dna2, Pole, Mcm2, Mcm3, Mcm5, Mcm6

5.70

33.75

Oocyte meiosis

Ccne2, Cdk1, Ccnb2, Plk1, SgoL1, Bub1, Fbxo5

2.82

10.27

p53 signalling pathway

Ccne2, Cdk1, Ccnb2, Rrm2, Chek1

2.44

12.23

Progesterone-mediated oocyte maturation

Cdk1, Ccnb2, Plk1, Bub1, Ccna2

1.81

9.93

Pyrimidine metabolism

Prim1, Rrm2, Pole, Tk1

1.54

7.03

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