Figure 1 | Scientific Reports

Figure 1

From: Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE

Figure 1

Comparison of hGIIE and hGIIA structures. (a) Superposition of the overall structure of hGIIE (gray, apo-hGIIE_1, crystal condition: without CaCl2) and hGIIA (pink, PDB: 3U8B), shown in ribbon representation. Secondary elements are numbered with either α (helices) or β (sheets). Catalytic dyad His46 and Asp90 are shown in red sticks. Calcium ions of hGIIE are shown as green spheres. Disulfide bonds are shown in line representation. (b) C-terminal region. Basic residues in hGIIA are labeled and shown in stick. Residues of hGIIE in the same place as hGIIA and other essential residues are also labeled and shown in stick. (c) The second calcium binding site. Calcium coordination in hGIIA is indicated by black dash lines. (d) Superposition of substrate binding pocket of hGIIE (gray), hGIIA (pink), and hGIIA-LY311727 (purple, PDB: 3U8D). Black arrows indicate the positional change of the residues in hGIIA structure upon binding with LY311727. (e) N-terminal region. Basic residues in hGIIA are labeled and shown in stick. Residues of hGIIE in the same place are also labeled and shown in stick.

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