Table 2 Comparison of proportion of patients in each consensus molecular subtype (CMS) and unclassified (UC) tumours from this study and the original classification study by the CRC subtyping consortium8, and enriched molecular pathways associated with subtypes from both studies.
From: Distinct gut microbiome patterns associate with consensus molecular subtypes of colorectal cancer
CMS1 MSI immune | CMS2 Canonical | CMS3 Metabolic | CMS4 Mesenchymal | Unclassified | |
|---|---|---|---|---|---|
CMS study8 | 14% | 37% | 13% | 23% | 13% |
Immune infiltration and activation | Wnt and Myc activation | Metabolic deregulation | Stromal infiltration, TGFβ activation, angiogenesis | ||
This study | 18% | 39% | 27% | 0% | 15% |
Immune infiltration and activation | Cell cycle signatures and Myc activation | Metabolic deregulation |
