Table 2 Summary of effects of IgG upon FXa activity in vitro.

From: Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

 

Inhibition of FXa activity (mean ± SEM; %)

Inhibition of FXa activity in the presence of ATIII* (mean ± SEM; %)

FXa activity –clotting time (seconds)

APS-IgG

9.7 ± 0.89

62.03 ± 1.36

74.2 ± 4.4

SLE-IgG

7.07 ± 1.28

81.40 ± 0.32

63.6 ± 2.7

HC-IgG

2.58 ± 0.6

80.16 ± 1.09

26.8 ± 0.6

  1. APS: Antiphospholipid syndrome, AT-III: Antithrombin III, HC: Healthy control, SEM: Standard error of mean,
  2. SLE: Systemic lupus erythematosus.
  3. *All compared to FXa-only (without IgG) inhibition by AT-III.
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