Figure 4 | Scientific Reports

Figure 4

From: Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses

Figure 4

Virus replication and histopathological examination of the lungs of the infected mice. Three mice per group were infected intranasally with 105 PFU of each virus and euthanized at 3 and 6 dpi, respectively, for internal body organ collection from the infected mice. Viral titers in the lungs (A) and lung weights (B) of the infected mice were represented in average. Error bars denote SD (* P < 0.05 and *** P < 0.001 compared with the rK/09 results). (C) Lung histopathology of the mice infected with rK/09, ma-P5, rΔ53–60, rNN58SS, and rN58T were evaluated using the H&E slides.

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