Figure 4
From: MITF and BRN2 contribute to metastatic growth after dissemination of melanoma
Depletion of MITF but not BRN2 reduces migration and invasion in vitro. (a,b) Migration or (c,d) invasion of cells depleted of MITF or BRN2. Cell migration was measured by wound healing assay, reduced migration was observed in (a) MM649 and (b) HT144 cells expressing shMITF. Quantitative cell invasion through Basement Membrane Matrix was measured in (c) MM649 and (d) HT144 cells ablated for MITF expression. Black blocks, vehicle only; white blocks, doxycycline. Values indicate mean +/− SD. *P < 0.05, **P < 0.01, ****P < 0.0001, unpaired t-test. SD, standard deviation.
