Figure 5

A predicted model for active flavonoid-induced apoptosis in H292 cells. Flavonoid induces cell apoptosis via inhibiting Bcl-2 and activation of caspase-3 dependant pathway. Lonchocarpin can occupy the BH3 binding groove, keeping them from restraining Bax and Bak. Bak or Bax can permeabilize the mitochondrial outer membrane and release cytochrome c, which results in activating caspase-9 and caspase-3.