Table 1 Comparison of the performance on Ebola antigen detection between the current FET biosensor and other published works/commercial products. For limit of detection, some studies utilized pfu/ml as a measure of virus concentration, while other studies including ours utilized ng/ml for protein concentration. There is no direct conversion between the two units.
From: Field-Effect Transistor Biosensor for Rapid Detection of Ebola Antigen
Technique | Target | Dispersion medium | Limit of detection | Processing time | |
|---|---|---|---|---|---|
Our work | FET | EGP | PBS, serum, plasma | 1 ng/ml | within a few seconds |
ReEBOVTM | chromatography | VP40 | blood, plasma | 625 ng/ml | 15–25 min |
Duan et al.9 | chromatography | EGP | serum | 100 ng/ml | 30 min |
Yen et al.8 | chromatography | EGP | serum | 150 ng/ml | |
Daaboul et al.10 | single-particle interferometric reflectance imaging sensor | pseudotyped Ebola virus | blood, serum | 5 × 103 pfu/ml | 2 h |
Yanik et al.12 | opto-fluidic nanoplasmonic | pseudotyped Ebola virus | PBS | 106 pfu/ml | 90 min |
Cai et al.11 | opto-fluidic chip | Ebola RNA | water | 0.2 pfu/ml | 3–10 min |
