Figure 3 | Scientific Reports

Figure 3

From: Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis

Figure 3

DHA inhibited UVB-induced papillomagenesis in hairless mouse skin. Female hairless mice (n = 15 per treatment group) were topically treated on their backs with DHA (10 µmol) 30 min prior to UVB radiation (180 mJ/cm2) three times a week until termination of the experiment at the 23rd week. (A) Representative photographs of animals from different treatment groups. (B) The average number of papillomas per mouse in different treatment groups. Results are expressed as means ± SD. ***p < 0.001 versus UVB-irradiated control group. (C) Formalin-fixed skin tissues of mice were subjected to H&E staining and immunohistochemical analysis using a specific antibody to detect STAT3 phosphorylation at Tyr705. Magnifications, ×200. Scale bar is 100 µm.

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