Table 2 PUFA composition in embryonic fibroblasts from fat-1 transgenic and WT mice.

From: Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis

  

WT MEF

fat-1 +/− MEF

Linoleic acid

C18:2

2.95 ± 0.08

1.51 ± 0.01c

γ-Linolenic acid

C18:3

0.07 ± 0.01

0.03 ± 0.01a

Arachidonic acid

C20:4

6.24 ± 0.13

3.89 ± 0.06c

ω-6 PUFAs (%)

 

9.26 ± 0.21

5.44 ± 0.05c

α-Linolenic acid

C18:3

0.17 ± 0.01

0.37 ± 0.03b

Eicosapentaenoic acid

C20:5

0.44 ± 0.01

1.56 ± 0.21b

Docosahexaenoic acid

C22:6

0.74 ± 0.02

2.67 ± 0.22c

ω-3 PUFAs (%)

 

1.35 ± 0.02

4.60 ± 0.08c

ω-6/ω-3 PUFAs

 

6.85 ± 0.10

1.19 ± 0.01c

ω-3/ω-6 PUFAs

 

0.15 ± 0.003

0.85 ± 0.01c

  1. The levels of representative PUFAs were measured as described in Methods.
  2. Data are expressed as means ± SE. (n = 3); a p < 0.05, b p < 0.01 and c p < 0.001 versus WT MEFs.
Back to article page