Table 3 Prediction performance of different diagnostic methods for different outcomes.

From: Performance of cervical phIGFBP-1 test alone or combined with short cervical length to predict spontaneous preterm birth in symptomatic women

 

Sensitivity (95% CI)

Specificity (95% CI)

PPV** (95% CI)

NPV† (95% CI)

LR + ° (95% CI)

LR −‡ (95% CI)

Delivery <7 days (frequency = 14/180 = 7.8%)

Cervical length <15 mm

85.7% (57.2–98.2%)

56% (48.1–63.7%)

14.1% (7.5–23.4%)

97.9% (92.6–99.7%)

2.0 (1.5–2.6)

0.2 (0.07–0.9)

ph-IGFBP1+

28.6% (8.4–58.1%)

89.8% (84.1–93.9%)

19% (5.5–41.9%)

93.7% (88.7–96.9%)

2.8 (1.1–7.2)

0.8 (0.6–1.1)

Positive combination test*

92.9% (66.1–99.8%)

51.8% (43.9–59.6%)

14% (7.7–22.7%)

98.9% (93.8–100%)

1.9 (1.6–2.4)

0.2 (0.02–0.9)

Delivery <14 days (frequency = 19/180 = 10.6%)

Cervical length <15 mm

84.2% (60.4–96.6%)

57.1% (49.1–64.9%)

18.8% (11.2–28.8%)

96.8% (91–99.3%)

2.0 (1.5–2.6)

0.2 (0.1–0.8)

ph-IGFBP1+

31.6% (12.6–56.6%)

90.7% (85.1–94.7%)

28.6% (11.3–52.2%)

91.8% (86.4–95.6%)

3.4 (1.5–7.7)

0.8 (0.5–1.0)

Positive combination test*

89.5% (66.9–98.7%)

52.8% (44.8–60.7%)

18.3% (11–27.6%)

97.7% (91.9–99.7%)

1.9 (1.5–2.4)

0.2 (0.05–0.7)

Delivery <34 weeks (frequency = 23/179 = 12.9%)

Cervical length <15 mm

82.6% (61.2–95%)

58.3% (50.2–66.2%)

22.6% (14.2–33%)

95.8% (89.6–98.8%)

2.0 (1.5–2.6)

0.3 (0.1–0.7)

ph-IGFBP1+

30.4% (13.2–52.9%)

91% (85.4–95%)

33.3% (14.6–57%)

89.9% (84.1–94.1%)

3.4 (1.5–7.5)

0.8 (0.6–1)

Positive combination test*

87% (66.4–97.2%)

53.8% (45.7–61.8%)

21.7% (13.8–31.6%)

96.6% (90.3–99.3%)

1.9 (1.5–2.4)

0.3 (0.1–0.7)

Delivery <37 weeks (frequency = 51/177 = 28.8%)

Cervical length <15 mm

72.5% (58.3–81.1%)

63.5% (54.4–71.9%)

44.6% (33.7–55.9%)

85.1% (76.3–91.6%)

2.0 (1.5–2.6)

0.4 (0.3–0.7)

ph-IGFBP1+

23.5% (12.8–37.5%)

92.9% (86.9–96.7%)

57.1% (34–78.2%)

75% (67.4–81.6%)

3.3 (1.5–7.3)

0.8 (0.7–1.0)

Positive combination test*

76.5% (62.5–87.2%)

58.7% (49.6–67.4%)

42.9% (32.5–53.7%)

86% (76.9–92.6%)

1.9 (1.4–2.4)

0.4 (0.2–0.7)

  1. *Positive test if cervical length <15 mm or if cervical length = 15–24.9 mm with positive ph IGFBP1. Negative test if cervical length = 15–24.9 mm with negative ph IGFBP1.
  2. **Positive Predictive value.
  3. °Negative predictive value.
  4. †Positive Likelihood ratio.
  5. ‡Negative Likelihood ratio.
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