Figure 1
From: Cholesterol-modified Hydroxychloroquine-loaded Nanocarriers in Bleomycin-induced Pulmonary Fibrosis
Chol-HCQ characterization. (a) The chemical structural of Chol-HCQ. (b) The Chol-HCQ 1H-NMR spectrum. 1H-NMR (400 MHz, CDCl3): δ = 8.51 (d, J = 5.4 Hz, 1 H, 9), 7.94 (d, J = 1.8 Hz, 1 H, 6), 7.70 (d, J = 9.0 Hz, 1 H, 3), 7.34 (dd, J = 8.9, 1.9 Hz, 1 H, 2), 6.42 (d, J = 5.5 Hz, 1 H, 8), 5.33 (s, 1 H, 12), 5.15 (d, J = 7.2 Hz, 1 H, 37), 4.68 − 4.54 (m, 1 H, 31), 4.16 (t, J = 6.1 Hz, 2 H, 22), 3.75 − 3.67 (m, 1 H, 13), 2.69 (t, J = 6.1 Hz, 2 H, 19), 2.66 − 2.41 (m, 9 H, 13, 17, 20, 25, 27), 2.29 (d, J = 7.9 Hz, 2 H, 32), 2.04 − 1.91 (m, 4 H), 1.86 − 1.79 (m, 3 H), 1.67 − 1.40 (m, 11 H), 1.37−1.29 (m, 6 H), 1.18 − 1.05 (m, 7 H), 1.02 − 0.98 (m, 7 H), 0.91 (d, J = 6.5 Hz, 3 H, 51), 0.86 (dd, J = 6.5, 1.2 Hz, 6 H, 56, 57), 0.67 (s, 3 H, 49). (c) The Chol-HCQ 13C-NMR spectrum. 13C-NMR (101 MHz, CDCl3): δ = 172.38 (24), 171.71 (28), 151.94 (9), 149.33 (5), 149.06 (7), 139.51 (33), 134.82 (1), 128.77 (6), 125.08 (3), 122.73 (37), 121.15 (2), 117.30 (4), 99.23 (8), 74.43 (31), 62.74 (22), 56.67 (17), 56.14 (41), 53.70 (47), 51.60 (19), 49.99 (13), 48.37 (40), 48.21 (20), 42.31 (42), 39.72 (54), 39.52 (43), 38.07 (32), 36.93 (35), 36.56 (34), 36.19 (52), 35.79 (50), 34.31 (38), 31.88 (39), 31.83 (25), 29.41 (27), 29.20 (36), 28.23 (55), 28.02 (46), 27.75 (45), 24.28 (53), 24.15 (15), 23.84 (16), 22.82 (57), 22.57 (56), 21.02 (14), 20.29 (44), 19.29 (51), 18.72 (48), 11.85 (21), 11.63 (49).
