Figure 5
From: Cholesterol-modified Hydroxychloroquine-loaded Nanocarriers in Bleomycin-induced Pulmonary Fibrosis
Preliminary safety evaluations of Chol-HCQ liposomes in female rats with bleomycin-induced pulmonary fibrosis. (a) Representative H&E images (400x) of vital organs including the heart, liver, spleen and kidney. Chol-HCQ and HCQ liposomes had no obvious toxicity on these tissues. (b) The concentrations of Chol-HCQ and HCQ in rat whole blood from 0 to 24 hours after intravenous administration of Chol-HCQ liposomes (total 20 mg/kg, Chol-HCQ 10 mg/kg) and HCQ sulphate (10 mg/kg) were assayed using high performance liquid chromatography (HPLC) (n = 5).
