Figure 2

The proliferation of allergen-specific CD4 T cells occurred primarily in the mLN during the maturation of memory CD4 T cells. (a) From day 7 post challenge, mice were given BrdU for 14 days. On day 22, mice were sacrificed and OVA-specific cells were analyzed using flow cytometry. (b) Representative contour plots of BrdU+ cells from OVA-specific CD4 T cells of spleen, mLN, lung, and airways. Similar experiments were performed twice.