Figure 5 | Scientific Reports

Figure 5

From: Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency

Figure 5

Ultrastructural changes in liver tissue induced by HoPan are prevented by P-PantSAc. Electron microscopy was used to analyze the ultrastructure of liver samples from untreated and treated mice. (a) Untreated mice. (b) Mice treated with CoA alone for 11 days. (c) Mice treated with HoPan for 5 days. (c’) Higher magnifications of inserts shown in (c,d) Mice treated with HoPan + CoA for 11 days. (e) Mice treated with HoPan + P-PantSAc for 11 days. ER = endoplasmic reticulum; G = glycogen; M = mitochondria; N = nucleus; l = lipid droplet. Scale bar represents 1 µm.

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