Figure 7
The importance of external tethering in the presence of negative transmural pressure (N = 1). (A) Left: image of isolated and cannulated mouse vessel pressurized at p in = p out = 3 cmH2O. Right: image of the same vessel at the same pressure with collagen surrounding the vessel. (B) Diameter traces showing contractions of isolated mouse vessel at p in = p out = 3, 1, 0.5, and 0 cmH2O (p e = 0.5 cmH2O for all cases) (left: without collagen, right: with collagen). (C) At p in = p out = 0 (negative transmural pressure) the vessel collapsed (left), but following gelation of collagen, the vessel lumen remained open and contractions continued.
