Table 3 Effect modification by age of randomization in the assessment of the effect of neonatal BCG at birth on T and B cel subsets.
0–1 days GMa | 2–7 days GM | 0–1 days GMRb (95% CI) | 2–7 days GMR (95% CI) | p valuec | |||||
|---|---|---|---|---|---|---|---|---|---|
BCG | No BCG | BCG | No BCG | BCG vs no BCG | BCG vs no BCG | ||||
Cell subsets (%) | 4 days | ||||||||
26d | 35 | 19 | 20 | ||||||
Tregs | 9.1 | 7.5 | 7.5 | 8.9 | 1.22 | (1.03–1.43) | 0.84 | (0.68–1.03) | 0.007 |
TH 17 cells | 0.6 | 0.6 | 0.9 | 0.6 | 1.01 | (0.73–1.40) | 1.42 | (0.95–2.11) | 0.19 |
TC 17 cells | 1.5 | 1.8 | 1.7 | 1.6 | 0.85 | (0.63–1.15) | 1.08 | (0.74–1.55) | 0.33 |
CD19 + CD24high + CD38high | 77 | 60 | 76 | 81 | 1.02 | (0.98–1.06) | 0.94 | (0.89–0.99) | 0.02 |
3 months | |||||||||
29 | 33 | 22 | 16 | ||||||
Tregs | 7.5 | 7.0 | 7.0 | 7.8 | 1.06 | (0.96–1.18) | 0.90 | (0.79–1.02) | 0.04 |
TH 17 cells | 1.5 | 1.5 | 1.6 | 1.2 | 1.02 | (0.84–1.24) | 1.40 | (1.11–1.79) | 0.04 |
TC 17 cells | 0.9 | 1.1 | 1.1 | 0.9 | 0.80 | (0.61–1.05) | 1.17 | (0.84–1.63) | 0.9 |
CD19 + CD24high + CD38high | 35 | 36 | 34 | 34 | 0.97 | (0.81–1.15) | 1.00 | (0.81–1.23) | 0.83 |
13 months | |||||||||
29 | 34 | 22 | 15 | ||||||
Tregs | 7.9 | 7.2 | 7.5 | 8.2 | 1.10 | (1.00–1.22) | 0.91 | (0.80–1.04) | 0.02 |
TH 17 cells | 2.3 | 2.2 | 2.5 | 2.1 | 1.05 | (0.87–1.26) | 1.15 | (0.89–1.47) | 0.56 |
TC 17 cells | 0.8 | 0.8 | 0.8 | 0.7 | 1.00 | (0.76–1.33) | 1.15 | (0.80–1.69) | 0.54 |
CD19 + CD24high + CD38high | 20 | 18 | 18 | 19 | 1.11 | (0.95–1.30) | 0.95 | (0.77–1.17) | 0.24 |