Figure 1
From: A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions
Scheme of chemical synthesis of DM-22. Reagents and conditions: a) (i) SOCl2, 80 °C, 2 h (ii) γ-aminobutyrric acid, NaOH, 5 °C → RT 12 h; b) NH2NH2, FeCl3, C, MeOH, 24 h; c) (i) catecholborane 1 M, P(OSiMe3)3, 1 h (ii) thiophosgene, NaHCO3 0.4 M, 2 h.
