Figure 6
From: A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions
DM-22 stimulates gene expression of osteogenic markers. (A–H) Box plots showing mRNA expression of osteogenic markers in hMSCs after D14 (A,C,E,G) or D21 (B,D,F,H) in culture in the presence of DM-22 or AL. Expression levels of: ALP (A-B), BSP (C-D); COLL I (E,F); COLLXV (G,H) are reported. Data were analyzed by GLM analysis. Data are expressed as mean ± 95% confidence interval of fold increase compared to CTRL cells (=1) of N = 4 independent experiments. *p < 0.05 vs control samples; °p < 0.05 DM-22 versus AL.
