Figure 3
From: A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease
The chronic administration of 24B3 ameliorated behavioral abnormalities in PS2Tg2576. (a) A protocol for the chronic administration of 24B3. PS2Tg2576 exhibits senile plaque accumulation from 2–3 months of age, and cognitive impairment from 4–5 months of age. Control-IgG, 82E1 and 24B3 (10 mg/kg/week) were intraperiosteally administered to PS2Tg2576 at from 3 months to 6 months of age. At 6 months of age, the behavioral tests were performed and the mice were sacrificed. Wt mice received PBS, which was administered at the same frequency as the antibodies. The numbers of mice in each group were as follows: Wt (n = 9), PS2Tg2576 + IgG (n = 7), PS2Tg2576 + 82E1 (n = 7), and PS2Tg2576 + 24B3 (n = 8). (b) The suppressive effect of 24B3 on behavioral abnormalities in elevated plus maze test. 24B3-treated PS2Tg2576 spent normal time in the open arm. (c) The suppressive effect of 24B3 on behavioral abnormality in nest construction test. The nest building ability of 24B3-treated PS2Tg2576 was restored. **p < 0.01, *p < 0.05.
