Figure 7
From: A Toxic Conformer of Aβ42 with a Turn at 22–23 is a Novel Therapeutic Target for Alzheimer’s Disease
A schematic illustration of the possible protective mechanism of 24B3. The toxic conformer of Aβ42 is assumed to directly bind to a certain acceptor via the toxic turn to trigger malignant signaling. 24B3 is assumed to mask the toxic turn to block binding to its acceptor, while 82E1 does not block binding. Thus, 24B3, but not 82E1, protects against cognitive impairment and neurotoxicity.
