Figure 1

Human methylome from integrated WGBS data. (a) Genome-wide average methylation level at CpGs (red line) and CpHs (blue bar) extracted from WGBS data. NEUR and Br represent neurons and brain tissues, respectively. The numbers followed by Br- means age of samples (d and y mean day and year, respectively). H1, H9, and HUES64 are human embryonic stem cell lines. Numbers at the end of the labels represent biological replicates. (b) WGBS samples hierarchically clustered by genome-wide CpG (left) and CpH (right) methylation levels. The whole genome was divided into 1 k-bp-long blocks and the average methylation levels of blocks were used to calculate the Pearson’s correlation coefficient (PCC). Colours in the x-axis represents the same cell (or tissue) types (blue: brain and neurons, red: ESCs, and yellow: other tissues).