Figure 3
From: Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver
Reduced HSC activation and hepatic fibrosis in smpd1+/− mice after polymicrobial sepsis. In long-term survivors (28 days following sepsis induction) (A) representative Sirius Red stainings, (B) hepatic fibrosis scores and Tgfb expression (Fig. 2A/B; n = 4 smpd1+/+, n = 7 smpd1+/−) and (C) hepatic gene expression of fibrosis-associated genes (Fig. 2C; n = 4 smpd1+/+, n = 8 smpd1+/−) were determined. Transcriptional expression is normalized to reference gene (Actb) and shown as log2 fold changes. Cut off values were set at ± 1, representing a variation of biological significance (dotted lines). #p < 0.05; ##p < 0.01 vs. corresponding smpd1+/+ control; *p < 0.05; * *p < 0.01 vs. baseline (MWU-test).
