Table 1 Summary of Clinical and Genetic Features of Individuals with L-ORD.

Family	Sample ID	Genotype	Protein	Status	Age of onset	Dark adaptation delay	Fundus appearance
Family	Sample ID	Genotype	Protein	Status	Age of onset	Dark adaptation delay	drusenoid deposits	RPE atrophy	macular degeneration
1	IV:I	Heterozygous c.646G>T	p.G216C	Affected	late 50s	yes	yes	yes	yes
	IV:II	Heterozygous c.646G>T	p.G216C	Affected	early 50s	yes	yes	yes	yes
	V:I	Heterozygous c.646G>T	p.G216C	Affected	mid-60s	yes	yes	yes	yes
	V:III	Heterozygous c.646G>T	p.G216C	Affected	late 50s	yes	yes	yes	yes
	V:VI	Heterozygous c.646G>T	p.G216C	Affected	mid-60s	yes	yes	no	no
	V:VII	Heterozygous c.646G>T	p.G216C	Affected	mid-60s	yes	yes	no	no
2	II:I	Heterozygous c.562C>A	p.P188T	Affected	mid-40s	yes	yes	yes	yes
	II:II	Heterozygous c.562C>A	p.P188T	Affected	mid-60s	yes	yes	yes	yes
	II:III	Heterozygous c.562C>A	p.P188T	Affected	late 50s	yes	yes	no	no
3	III:I	Heterozygous c.489C>A	p.S163R	Affected	mid-60s	yes	yes	yes	yes

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