Table 3 Characteristics of the patients with decreased or non-decreased PD-L1 expression on tumor cells between pre- and post-CCRT specimens.
Patient characteristics | Decreased (%) (N = 16) | Not decreased (%) (N = 19) | P-value |
|---|---|---|---|
Age (years) | |||
Mean (SD) | 61.1 (10.4) | 63.9 (10.4) | 0.428 |
Sex | |||
male | 13 (81) | 15 (79) | 0.865 |
female | 3 (19) | 4 (21) | |
Smoking status | |||
never-smoker | 1 (6) | 4 (21) | 0.349 |
current or former smoker | 15 (94) | 15 (79) | |
Histology | |||
squamous | 7 (44) | 11 (58) | 0.406 |
Non-squamous | 9 (56) | 8 (42) | |
Stage | |||
II | 6 (38) | 8 (42) | 0.782 |
III | 10 (62) | 11 (58) | |
Chemo-radiation therapy regimen | |||
Vinorelbine based | 11 (69) | 14 (74) | 0.748 |
Taxan based * | 3 (19) | 5 (26) | 0.594 |
Radiotherapy dose | |||
40Gy | 13 (81) | 18 (95) | 0.206 |
50Gy | 3 (19) | 1 (5) | |
Down staging | |||
Yes | 11 (69) | 11 (58) | 0.507 |
No | 5 (31) | 8 (42) | |
Change in stromal CD8+ lymphocyte status after CCRT ** | |||
Increased | 3 (19) | 14 (78) | <0.001 |
Unchanged or decreased | 13 (81) | 4 (22) | |
